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Biological nanopores for biopolymer sensing and sequencing based on FraC actinoporin
Biological nanopores for biopolymer sensing and sequencing based on FraC actinoporin
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机译:基于FraC放线菌素的生物纳米孔用于生物聚合物传感和测序
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摘要
The invention relates generally to the field of nanopores and the use thereof in various applications, such as analysis of biopolymer s and macromolecules, typically by making electrical measurements during translocation through a nanopores. Provided is a system comprising a funnel- shaped proteinaceous nanopore comprising an a-helical pore-forming toxin that is a member from the actinoporin protein family, more in particular Fragaceatoxin C (FraC), a mutant FraC, a FraC paralog, or a FraC homolog.
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