composition, pharmaceutical composition, vaccine, method for inducing antibodies in an individual, method for treating cancer in a patient in need thereof and method for inducing or ameliorating the immune reaction in an individual in need thereof

摘要

The present disclosure covers immunogenic / therapeutic compositions including glyco-conjugates and globe series antigens (ssea-4, globe h or ssea-3) and therapeutic adjuvants (obi-821 or obi-834), as well as methods for preparing and using the even to treat proliferative diseases such as cancer. therapeutic conjugates include an antigen attached to a carrier. in particular, the therapeutic conjugates include a bone-4, h-globe or bone-3 portion and a subunit of the kHI moiety linked via a ligand. Therapeutic compositions are in part intended to act as cancer vaccines (single valiant, bivalent, or trivalent vaccines) to boost the body's natural ability to protect itself through the immune system from damage from damaged or abnormal cells such as like, cancer cells. Examples of immune responses may be characterized by reduced disease severity, including but not limited to disease prevention, delayed onset of disease, decreased symptom severity, decreased morbidity, and delayed mortality.