The present invention provides a method for detecting antibodies in a sample from a subject, wherein the antibodies bind to the epitopes of mycobacterium tuberculosis antigens, which comprises contacting the sample with two or more isolated polypeptides or antigenic fragments or variants thereof. same, wherein the polypeptides comprise polypeptides selected from the group consisting of: 1, 3, 5, 7, 9, 11, 13, and 15; and detecting the formation of isolated antibody-peptide complexes comprising said polypeptides or antigenic fragments or variants thereof, wherein the formation of said complexes is indicative of the presence of antibodies to epitopes of mycobacterium tuberculosis antigens in said sample.
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