The present invention provides a method of detecting antibodies in a sample from a subject, wherein the antibodies bind to epitopes of Mycobacterium tuberculosis antigens, comprising contacting the sample with two or more isolated polypeptides or antigenic fragments or variants thereof, wherein the polypeptides comprise polypeptides selected from the group consisting of SEQ ID NOS: 1, 3, 5, 7, 9, 11, 13, and 15; and detecting formation of antibody-peptide complexes comprising said isolated polypeptides or antigenic fragments or variants thereof, wherein formation of said complexes is indicative of the presence of the antibodies to epitopes of Mycobacterium tuberculosis antigens in said sample.
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机译：本发明提供了一种检测来自受试者的样品中的抗体的方法，其中所述抗体结合结核分枝杆菌抗原的表位，包括使样品与两种或更多种分离的多肽或其抗原性片段或变体接触，其中所述多肽包含所选择的多肽选自SEQ ID NOS：1、3、5、7、9、11、13和15;检测包含所述分离的多肽或其抗原性片段或变体的抗体-肽复合物的形成，其中所述复合物的形成指示在所述样品中存在针对结核分枝杆菌抗原的表位的抗体。
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