a combined composition for preventing or treating cancer comprising benzophenone thiazole derivatives as a vda and topoisomerase inhibitor

摘要

The present invention relates to a combined pharmaceutical composition for the prevention or treatment of cancer comprising a compound of formula 1 or a pharmaceutically acceptable salt thereof and a topoisomerase inhibitor as active ingredients. The combined pharmaceutical composition of the present invention specifically inhibits cell proliferation and induces apoptosis as for various cancers, such as colorectal cancer and ovarian cancer that a vascular rupture agent cannot treat due to a complex neoplasm inhibition mechanism of the compound. of formula 1 and the pharmaceutically acceptable salt of the same salt and topoisomerase inhibitor, and thus may usefully be used for cancer prevention and treatment.