methods for determining risks associated with cardiovascular disease and for building a risk prognostic model; and, using detection of mmp-8 and crp.

摘要

The present invention relates to a novel method for determining cardiovascular disease risk comprising detecting mmp-8 and crp in a sample, and comparing the amounts detected with respective predetermined values of mmp-8 and crp, wherein the detection of elevated levels of mmp-8 and crp is indicative of the presence or risk of cardiovascular event or disease. The present invention also relates to the use of mmp-8 and CRP detection to predict a risk for acquiring a cardiovascular event, to monitor the effect of therapy on the cardiovascular event or cardiovascular disease, or to detect the presence of a subclinical cardiovascular disease. Also, a method for constructing a risk prediction model for a presence of cvd disease or a risk of cvd events is presented.