non-hla restricted t cell vaccines of hpv16, compositions and methods of use thereof

摘要

The present invention relates to human papillomovirus immunogenic compositions and methods of using them. the compositions comprise multi-epitope peptide sequences specifically selected and designed to be effectively processed and cross-presented to t cells. The peptides used in the compositions exhibit high levels of binding to hla supertypes. Immunogenic compositions are broadly applicable to large proportions of target populations. The compositions comprise adjuvants such as cationic lipids.