Methods of treating upper tract urothelial carcinomas

摘要

The invention relates to methods for locally delivering a chemotherapeutic agent to a cutaneous urothelial carcinoma (cuts). The methods involve placing a balloon catheter that has a working channel and a balloon in the ureter / renal pelvis via retrograde or anterograde urethral access; inflate the catheter balloon to temporarily obstruct the ureter; infuse (instill) a liposomal formulation containing a chemotherapeutic agent into the catheter working channel; and allowing the infused liposomal formulation to remain in the ureter and / or renal pelvis for a sufficient period of time to allow at least a portion of the liposomal formulation to adhere to the urothelial wall. In the methods of the invention, at least a portion of the infused chemotherapeutic formulation adheres to the urothelial wall while it is instilled and remains in the ureter and / or renal pelvis. The disclosed methods may be performed as an adjunctive therapy to other methods of treating cuts, such as ureteroscopic ablation or tumor resection.