anti-erythrocyte antibody analysis in the presence of antibody directed against a surface-bound erythrocyte antigen

摘要

The present invention relates to an analytical method for detecting antibody in human blood serum, the antibody of which is directed against blood group antigen, wherein the serum contains an additional antibody directed against a surface antigen by contacting the serum to be analyzed with blood cell membranes, which naturally carry surface blood group antigens, followed by agglutination detection that indicated the presence of antibody directed against at least one surface antigen of the blood cell membranes. The agglutination reaction caused by the additional antibody is prevented, allowing detection of anti-blood group antibody.