Method for the preparation of a micropartu00eccula prolonged release and prolonged release micropartu00eccula thus obtained

摘要

Method for the preparation of a micropartu00eccula prolonged release and prolonged release micropartu00eccula thus obtained.Method for preparing microparticles comprising a prolonged release release a physiologically active substance for a long period of time.The prolonged release microparticles are prepared by a process of multiemulsu00e3o.A drug of interest is dissolved or dispersed in each of at least two oils to provide at least two phases of primary oil or emulsions.Each stage of the oil or emulsion contains a biodegradable polymer. The at least two phases of oil emulsions are dispersed in a primary or aqueous phase, synchronously or in succession.The drug dispersed solution, organic solvents are removed to produce microparticles.Therefore, the drug release of luteinizing hormu00f3nio 's hormones can be continuously released u00ed n live for extended periods of time.Bringing significant improvement in therapeutic effects.