n- (4- (1- (2,6-difluorobenzyl) -5 - ((dimethylamino) methyl) -3- (6-methoxy-3-pyridazinyl) -2,4-dioxo-1,2,3 compound, 4-Tetrahydrothieno 2,3-d pyrimidin-6-yl) phenyl) -N'-methoxyurea, or a salt thereof, pharmaceutical, and use of the compound

摘要

"Compound, prodrug, pharmaceutical, method of antagonizing gonadotropin-releasing hormone, and use of the compound." The present invention provides a compound represented by the formula wherein R 1 is C 1-4 alkyl, R 2 is (1) a 5- to 7-membered nitrogen-containing heterocyclic group which may have a selected substituent from the group consisting of (1 39) halogen, (2 39) a hydroxy group, (3 39) a c 1-4-alkyl and (4 39) a c ~ 1-4 alkoxy, (2) a phenyl which may have a substituent selected from the group consisting of (1 39) a halogen, (2 39) a C1-4-alkoxy-C1-4-alkyl , (3 39) a mono-C1-4-alkylcarbamoyl-C1-4-alkyl, (4 39) a C1-4-alkoxy and (5 39) a mono- C 1-4 alkylcarbamoyl C 1-4 alkoxy or the like; R3 is a C1-4 alkyl; R4 is a C1-4 alkoxy or the like; n is an integer from 1 to 4; or a salt thereof, as a thienopyrimidine compound having gonadotropin releasing hormone antagonist activity.