USE OF APL TYPE PEPTIDE FOR TREATMENT OF INTESTINAL INFLAMMATORY DISEASES AND TYPE 1 DIABETES.

摘要

The use of an apl-like peptide for the treatment of inflammatory bowel disease and type 1 diabetes. The present invention relates to the field of medicine, particularly the use of an apl-like peptide derived from the human 60 kDa heat stress protein or analogs thereof. the manufacture of a pharmaceutical composition for the treatment of crohn's disease, ulcerative colitis and type i diabetes mellitus. said peptide biodistributes in the gastrointestinal tract and promotes the induction of apoptosis of activated t-cells from the intestinal lamina propria and peripheral blood of patients with crohn's disease. In addition, this peptide apoptosis in mononuclear cells of patients with diabetes mellitus.