PROCESS FOR PREPARING A COMPOUND, PROCESS FOR PREPARING 3-AMINO-2,2-DIMETHYLPROPANAMIDE, PROCESS FOR PREPARING A THERAPEUTIC, PROPHYLATIC OR DIAGNOSTIC AGENT, PROCESS FOR PREPARING ALISQUIREN, PROCESS FOR PREPARING A PREPOSE OF PREPOSE , USE OF 3-AMINO-2,2-DIMETHYLPROPANAMIDE AND USE OF THERAPEUTIC, PROPHYLATIC OR DIAGNOSTIC AGENTS.

摘要

Process for Dimethylating Active Methylene Groups The present invention discloses a process for dimethylating active methylene groups. Specifically, the invention discloses a process for preparing 3-amino-2,2-dimethylpropanamide. Compounds produced by the present dimethylation process such as 3-amino-2,2-dimethylpropanamide may be used as intermediates in the therapeutic, prophylactic or diagnostic agent synthesis pathway, for example aliskiren or cryptophycin. particularly, the invention relates to embodiments further comprising the processes for preparing the pharmaceutical dosage form comprising said therapeutic, prophylactic or diagnostic agents. More specifically, the invention relates to the use of the compounds produced by the present dimethylation process for the manufacture of therapeutic, prophylactic or diagnostic agents or for the manufacture of pharmaceutical dosage forms comprising said therapeutic, prophylactic or diagnostic agents. The processes according to the present invention may be beneficially applied for the synthesis of various active pharmaceutical ingredients, such as aliskiren or cryptophycin.