PHARMACEUTICAL COMPOSITION FORMED ORAL ADMINISTRATION UNDERSTANDING A LAYER UNDERSTANDING A MODIFIED RELEASE PART AND A LAYER UNDERSTANDING AN IMMEDIATE RELEASE PART

摘要

A pharmaceutical composition formulated for oral administration comprising a layer comprising a modified release portion and a layer comprising an immediate release portion. The present invention relates to a pharmaceutical composition for oral administration comprising a modified release portion containing tamsulosin or a pharmaceutically acceptable salt thereof. same, and an immediate release moiety containing solifenacin or a pharmaceutically acceptable salt thereof and a hydrophilic substance. In the pharmaceutical composition, the dissolution rate of each drug (in particular, solifenacin contained in the immediate release portion) is similar to that of current single drug formulations and the maximum percentage of dissolution of each drug (in particular, solifenacin contained in the portion of immediate release). immediate release) is 90% or more. therefore, the pharmaceutical composition is a single formulation (i.e. a combined formulation) with a bioavailability equivalent to that of current single drug formulations.