Substituted aminobutyric derivatives as neprilysin inhibitors, their use, pharmaceutical composition, combination and method for inhibiting neutral endopeptidase activity.

摘要

The present invention provides a compound of formula I'; or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , X and n are defined herein. The invention also relates to a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.