Recombinant bovine follicle stimulating hormone, which comprises the composition and Method for superovulation and synchronization of estrus in cattle using the hormone

摘要

The present Invention relates to the technical field of Biotechnology and the production of molecules via recombinantThis relates in particular to a polinucleotídica Synthetic Sequence encoding a recombinant bovine follicle stimulating hormone of simple Chain,That includes a First polinucleótido encoding the beta subunit of follicle stimulating hormone from Bos taurus Sequence SEC ID no.1Or a variant of it with at least 85% Sequence identity with this; a Second polinucleótido which encodes the alpha Subunit of follicle stimulating hormone sequence of Bos TaurusSEC ID no.2 or a variant of it with at least 85% Sequence identity with this; and a Third polinucleótido Connecting these first and second polynucleotides.Which encodes a sequence Space derived from the sequence of Human Keratin 10 sec id no. 3 or a Variant.The Invention also includes the Gene Construct that includes these sequences.Cells transformed with the same and Pharmaceutical composition comprising the recombinant bovine follicle stimulating hormone of simple Chain.