Pharmaceutical compositions for Combined Therapy (Divisional Application 201701983)

摘要

The present Invention relates to a Pharmaceutical composition comprising a combination of an FXR agonist and at least a Lipid Lowering Agent (e.g.An agonist of PPAR alpha, PPAR Delta agonist agonist, dual PPAR alpha and Delta, and / or statin).It also describes the use of the combination for the Treatment or prevention of a disease or AFECCIÓN mediated FXR, such as primary biliary cirrhosis (PBC),Primary sclerosing cholangitis (PSC), portal hypertension, diarrhea by Bile acids, NAFLD (non-alcoholic fatty liver disease;), Nash (nonalcoholic steatohepatitis induced by alcohol)And other chronic Liver Diseases.The combination of this Invention is useful for the Treatment or prevention of diseases associated with elevated levels of Lipids and liver Enzymes.The present Invention also relates to kits or packages that include the pharmaceutical combination.