首页> 外国专利> (6S, 9aS) -N-benzyl-6 - ((4-hydroxyphenyl) methyl) -4,7-dioxo-8 - ((6- (3- (piperazin-1-yl) azetidin-1-yl) pyridine -2-yl) methyl) -2- (prop-2-ene-1-yl) octahydro-1H-pyrazino (2,1-c) (1,2,4) triazin-1-carboxamide COMPOUND

(6S, 9aS) -N-benzyl-6 - ((4-hydroxyphenyl) methyl) -4,7-dioxo-8 - ((6- (3- (piperazin-1-yl) azetidin-1-yl) pyridine -2-yl) methyl) -2- (prop-2-ene-1-yl) octahydro-1H-pyrazino (2,1-c) (1,2,4) triazin-1-carboxamide COMPOUND

机译:(6S,9aS)-N-苄基-6-((4-羟苯基)甲基)-4,7-二氧-8-((6-(3-(哌嗪-1-基)氮杂环丁烷-1-基)吡啶-2-基)甲基)-2-(丙-2-烯-1-基)八氢-1H-吡嗪并(2,1-c)(1,2,4)三嗪-1-羧酰胺化合物

摘要

A compound represented by formula (1) or pharmaceutically acceptable salt thereof: wherein R 1 is a C 1-6 alkyl group; R 2 and R 3 are the same or different from each other and each is a hydrogen atom or a C 1-6 alkyl group; X 2 , X 3 and X 4 are the same or different from each other and each is a hydrogen atom or a halogen atom; and X 5 is a hydrogen atom or - P(=O)(OH) 2 has a Wnt Pathway modulating activity.
机译:式(1)表示的化合物或其药学上可接受的盐:其中R 1为C 1-6烷基; R 2和R 3相同或不同,分别为氢原子或碳数1〜6的烷基。 X 2,X 3和X 4相同或不同,分别为氢原子或卤素原子。 X 5为氢原子或-P(= O)(OH)2具有Wnt途径调节活性。

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