BISPECIFIC TO EGFR / C-MET ANTIBODIES

摘要

The invention relates to bispecific to EGFR and / or c-Met antibodies and methods for producing and using molecules. The epidermal growth factor receptor (EGFR, ErbB1 or HERI) is a type I 170 kDa transmembrane glycoprotein encoded by the c-ErbB1 proto-oncogene. EGFR is a member of the epidermal growth factor (HER) human receptor family, which are receptor tyrosine kinases (RTKs), including HER2 (ErbB2), HER3 (ErbB3) and HER4 (ErbB4). EGFR signaling is initiated by ligand binding, followed by induction of a conformational change, homodimerization or heterodimerization of the receptor with other members of the ErbB family.