MICROORGANISM WITH MODIFIED ALDEHYDE ACTIVITY: FERREDOXIN OXIDORUTCUTASES AND RELATED METHODS

摘要

This invention provides a non-naturally occurring bacterium with reduced or eliminated enzyme activity that catalyzes a reaction, as determined by EC 1.2.7.5, such as aldehyde: ferredoxin oxidoreductase (AOR). Optionally, said bacterium also has a reduced or eliminated enzyme activity that catalyzes the reaction, as determined by EC 1.2.1.10 and / or EC 1.1.1.1, such as aldehyde dehydrogenase, alcohol dehydrogenase, or bifunctional aldehyde / alcohol dehydrogenase. In addition, this invention provides methods for producing products by culturing said bacterium in the presence of a gaseous substrate containing one or more CO, CO, and H.