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Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods
Microorganism with modified aldehyde:ferredoxin oxidoreductase activity and related methods
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机译:修饰醛的微生物:铁氧还蛋白氧化还原酶活性及相关方法
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摘要
The invention provides a non-naturally occurring bacterium having decreased or eliminated activity of an enzyme that catalyzes the reaction defined by EC 1.2.7.5, such as aldehyde:ferredoxin oxidoreductase (AOR). Optionally, the bacterium also has decreased or eliminated activity of an enzyme that catalyzes the reaction defined by EC 1.2.1.10 and/or EC 1.1.1.1, such as aldehyde dehydrogenase, alcohol dehydrogenase, or bifunctional aldehyde/alcohol dehydrogenase. The invention further provides methods of producing products by culturing the bacterium in the presence of a gaseous substrate containing one or more of CO, CO2, and H2.
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