首页> 外国专利> USE OF TORASEMIDE FOR TREATING ALZHEIMER'S DISEASE OR AN ALZHEIMER'S DISEASE RELATED DISORDER OR SPINAL CORD INJURY

USE OF TORASEMIDE FOR TREATING ALZHEIMER'S DISEASE OR AN ALZHEIMER'S DISEASE RELATED DISORDER OR SPINAL CORD INJURY

机译:使用托拉杀米治疗老年痴呆症或与老年痴呆症有关的疾病或脊髓损伤

摘要

The present invention discloses the use of torasemide or a combination of torasemide with a second compound for the treatment of Alzheimer's disease or an Alzheimer's disease related disorder or spinal cord injury and for protecting cortical neurons or brain endothelial cells against Aβ1-42 peptide toxicity. The invention further discloses the use of torasemide or a combination of torasemide with a second compound for the preparation of a medicament for the treatment of Alzheimer's disease or an Alzheimer's disease related disorder or spinal cord injury and for the preparation of a medicament for protecting cortical neurons or brain endothelial cells against Aβ1-42 peptide toxicity. The invention also discloses a method for the treatment of Alzheimer's disease or an Alzheimer's disease related disorder or spinal cord injury comprising administering torasemide or a combination of torasemide with a second compound to a subject.
机译:本发明公开了托拉塞米或托拉塞米与第二种化合物的组合在治疗阿尔茨海默氏病或​​与阿尔茨海默氏病有关的疾病或脊髓损伤以及保护皮质神经元或脑内皮细胞抵抗Aβ<1-42的用途中的用途肽毒性。本发明进一步公开了托拉塞米或托拉塞米与第二种化合物的组合在制备用于治疗阿尔茨海默氏病或​​与阿尔茨海默氏病相关的疾病或脊髓损伤的药物以及制备用于保护皮层神经元的药物中的用途。或脑内皮细胞对Aβ 1-42 肽的毒性作用本发明还公开了一种用于治疗阿尔茨海默氏病或​​与阿尔茨海默氏病相关的疾病或脊髓损伤的方法,该方法包括将托拉塞米或托拉塞米与第二种化合物的组合给予受试者。

著录项

  • 公开/公告号EA032881B1

    专利类型

  • 公开/公告日2019-07-31

    原文格式PDF

  • 申请/专利权人 PHARNEXT;

    申请/专利号EA20130000975

  • 发明设计人 DANIEL;ILYA;SERGUEI;EMMANUEL;MICKAEL;

    申请日2012-03-01

  • 分类号A61K31/138;A61K31/445;A61K31/4709;A61K31/48;A61K31/495;A61K31/64;A61P25/28;A61K31/28;

  • 国家 EA

  • 入库时间 2022-08-21 12:02:28

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