2-ACETYL-6- (2- (2- (4-BROMBENZYLIDENE) HYDRAZINYL) THIAZOL-4-IL) -3,7,9-TRHYDROXY-8,9b-DIMETHYLDIBENZO b, d FURAN-1 (9bH) -ON, MANIFESTING AN INHIBITING ACTION REGARDING THE HUMAN TYROSIL-DNA-PHOSPHODESTERASE 1 Enzyme

摘要

The invention relates to molecular biology, biochemistry and biotechnology, specifically to a compound representing 2-acetyl-6- (2- (2- (4-bromobenzylidene) hydrazinyl) thiazol-4-yl) -3,7,9-trihydroxy- 8,9b-dimethyldibenzo [b, d] furan-1 (9bH) -one, a hydrazinothiazole derivative of usnic acid of formula I, which is capable of inhibiting the action of the human tyrosyl DNA phosphodiesterase 1 enzyme. Technical results: increased inhibitory effect on the enzyme tyrosyl-DNA phosphodiesterase 1 person (Tdp1) and the expansion of the arsenal of inhibitors of this enzyme.