Flavones glycoside drug intermediates acetylene carboxylic acid synthesis method

摘要

The present invention discloses flavones glycoside drug intermediates acetylene carboxylic acid synthesis method, comprises the following steps: 3-propargyl, sodium nitrate solution were added to the reaction vessel, controlled the stirring speed, controlled the temperature of the solution, reacted, added ethyl tert butyl ether solution, raised the temperature of the solution, reacted., added antimony pentachloride powder, and dihydrin diacetate solution, raised the temperature of the solution, continued to react, extracted several times with ethyl tert butyl ether solution, set aside, solution stratification, separated reservoir, washed with the potassium chloride solution for several times, washed with the 3-methyl-2-amyl ketone solution for several times, washed with the dipropylene glycol solution for several times, re-crystallized in the 1, 3-dimethylcyclohexane solution, dehydrated with dehydration, got the finished product acetylene carboxylic acid.