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Organic synthesis intermediates 2-aminobenzothiazole synthesis method

机译:有机合成中间体2-氨基苯并噻唑的合成方法

摘要

Organic synthesis intermediates 2-aminobenzothiazole synthesis method, comprises the following steps: 3 mol aniline and 12 L isopropyl alcohol solution were added to the reaction vessel, the stirring speed was controlled at 110-130 rpm, 1.6 L hydrochloric acid solution and 4-5 mol 2-methylthiocyanobenzene were added, and the temperature of the solution was raised to 60-70 °C, control the stirring speed at 130-150 rpm, keep for 90-120 min, reduce the solution temperature to 40-45 °C, reflux for 60-80 min, stand for cooling, crystal precipitated, the crystal dissolved in cyclohexane solution, vacuum distillation, collecting 80-90 °C fraction, adding 8L oxalic acid solution, lowering the solution temperature to 10-16'C, precipitated crystals, filter it, washed with triethylamine solution, washed with ethylene glycol dimethyl ether solution, dehydrated with dehydrating agent.
机译:有机合成中间体2-氨基苯并噻唑的合成方法,包括以下步骤:将3mol苯胺和12L异丙醇溶液加入反应容器中,搅拌速度控制在110-130rpm,1.6L盐酸溶液和4-5加入mol 2-甲基硫氰基苯,将溶液温度升至60-70℃,将搅拌速度控制在130-150rpm,保持90-120min,将溶液温度降至40-45℃,回流60-80分钟,放置冷却,晶体沉淀,将晶体溶解在环己烷溶液中,真空蒸馏,收集80-90℃的馏分,加入8L草酸溶液,将溶液温度降至10-16'C,沉淀结晶,过滤,用三乙胺溶液洗涤,用乙二醇二甲醚溶液洗涤,用脱水剂脱水。

著录项

  • 公开/公告号IES86995B2

    专利类型

  • 公开/公告日2019-05-01

    原文格式PDF

  • 申请/专利权人 CHENGDU ZHONG HENG HUA TIE TECHNOLOGY CO.LTD.;

    申请/专利号IES20180095

  • 发明设计人 XIANGLIANG PENG;

    申请日2018-04-03

  • 分类号C07D277;

  • 国家 IE

  • 入库时间 2022-08-21 12:02:17

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