Antitumor drug intermediates 3, 5-tert-butyl-4-hydroxy benzoic acid synthesis method

摘要

The present invention discloses antitumor drug intermediates 3, 5-tart-butyl-4-hydroxy benzoic acid synthesis method, comprises the following steps:2-amino-3, 5-tort butyl-4-hydroxy-6-benzyl bromide, sodium sulfate solution were added to the reaction vessel, controlled the stirring speed, controlled the temperature of the solution, reacted, added nitro-methane solution, raised the temperature of the solution, stirred speed, continued to react; added diethyl glutarate solution, and niobium pentachloride powder, reacted, washed with the sodium bromide solution for several times, added oxalic acid solution, adjusted the, washed with the 1, 2-diphenyl ethane solution for several times, re-crystallized in the dibutylamine solution, dehydrated with dehydration, got the finished product 3, 5-tert-butyl-4-hydroxy benzoic acid. Figure 1