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Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
Method for reducing the thromboembolic potential of a plasma-derived immunoglobulin composition
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机译:降低血浆来源的免疫球蛋白组合物的血栓栓塞潜力的方法
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摘要
The present invention provides methods for reducing the amidolytic and anti-complement activity (ACA) content of an immunoglobulin composition through the use of cation exchange chromatography. In a specific embodiment, the invention provides methods for reducing the Factor XI and/or Factor XIa and/or ACA content of an immunoglobulin composition by collecting the leading portion of a cation exchange eluate. The present invention also provides immunoglobulin composition having reduced levels of amidolytic activity, Factor XI, and/or Factor XIa, and/or ACA content.
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