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Methods and systems for screening candidate compounds for their potential to cause systemic or hepatic toxicity
Methods and systems for screening candidate compounds for their potential to cause systemic or hepatic toxicity
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机译:用于筛选候选化合物引起全身或肝脏毒性的方法和系统
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摘要
Methods of screening a compound for susceptibility to causing systemic or hepatic toxicity, using a hepatic cell system exposed to a range of concentrations of a bile acid in the absence or presence of a compound to determine a toxicity profile. In vitro systems for predicting in vivo hepatotoxic potential of a compound are also provided, and include in vitro cultured hepatic cell systems with a capacity for bile acid synthesis, bile acid transport and bile acid regulation.
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