Functional Cardiorespiratory Toxicity Screening of Candidate Antiparasitic Drugsand Antidotes for Chemical Poisons (Study of the Effects of Drugs Upon the Cardiovascular and Respiratory Systems)

摘要

The purpose of these studies is to determine the cardiovascular and pulmonaryeffects of intravenous or intramuscular injections of candidate antiparasitic drugs, and antidotes for chemical poisons. Preliminary studies will be done to ascertain methods and dose ranges. All experiments will incorporate the following physiological methods; cardiovascular measures; arterial blood pressure, left ventricular pressure, dP/dt, left ventricular and diastolic pressure, ECG readings--PR intervals and QTc determinations, heart rate, pulmonary artery pressure, pulmonary wedge pressure, and pulmonary vascular resistance; pulmonary ventilatory measures: air flow, transpulmonary pressure, tidal volume, minute volume, compliance, resistance and respiratory rate; and Hematological Measures: pO2, pCO2, pH and microhematocrits. In this report are summaries of our activities for the contract period. (Author)