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Methods for treating muscle wasting and bone disease using novel hybrid actriib ligand trap proteins
Methods for treating muscle wasting and bone disease using novel hybrid actriib ligand trap proteins
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机译:使用新型混合型Actriib配体捕获蛋白治疗肌肉萎缩和骨骼疾病的方法
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摘要
The present disclosure describes novel hybrid soluble ActRIIB-ECD polypeptides which fully retain binding affinity for myostatin and activin A but demonstrate significantly reduced binding to BMPs, especially BMP-9. The novel compositions described herein can be used to prepare novel hybrid ActRIIB ligand trap proteins, which can be used for modulating the growth of muscle, bone, cartilage, fat, fibroblast, blood and neuronal tissue to counteract muscle wasting, bone loss, anemia, inflammation and fibrosis in a therapeutically meaningful manner. Because these novel next-generation myostatin/activin inhibitors are safer and more effective molecules than the currently available myostatin inhibitors, they are useful in a wide variety of clinical indications.
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