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NON-ANTAGONISTIC ANTIBODIES DIRECTED AGAINST THE ALPHA CHAIN OF THE IL7 RECEPTOR EXTRACELLULAR DOMAIN AND USE THEREOF IN CANCER TREATMENT
NON-ANTAGONISTIC ANTIBODIES DIRECTED AGAINST THE ALPHA CHAIN OF THE IL7 RECEPTOR EXTRACELLULAR DOMAIN AND USE THEREOF IN CANCER TREATMENT
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机译:针对IL7受体胞外域α链的非抗性抗体,并在癌症治疗中使用
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摘要
The description concerns humanized antibodies directed against the extracellular domain of the alpha chain of the receptor for interleukin-7 (IL-7), especially against the receptor for human IL-7 expressed on human cells (also designated human Th-7Ralpha or IL-7Ra or CD127) and which do not interfere with the IL-7 or TSLP signaling pathways. The antibodies described do not have an antagonistic effect on the IL-7 receptor, but may still present cytotoxic activity against CD127 positive cells. In a particular embodiment, the antibody does not have an agonist effect on the IL-7 receptor.
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