Process for producing the coordinative compound of copper(II): bis(m2-1-(7-chloro-6-methyl-2,3-bis(pyridin-2-yl)-5H-cyclopentabpyrazin-5-yl)ethanone)-dichloro-di-copper(II) methanol solvate

摘要

The invention relates to the chemistry of coordinative compounds, namely to metal-organic complex compounds of copper(II) with pyrazine and pyridine derivatives, in particular to the class of 2,3-bis(2-pyridyl)pyrazine. Due to their antimicrobial and antitumor activity, these compounds may be promising candidates for use in medicine.According to the invention, a process for producing the coordinative compound bis(µ2-1-(7-chloro-6-methyl-2,3-bis(pyridin-2-yl)-5H-cyclopenta[b]pyrazin-5-yl)ethanone)-dichloro-di-copper(II) methanol solvate is claimed, with the formula [Cu2(acdpp)2Cl2]·2(CH3OH), which consists in dissolving copper(II) chloride dihydrate and 2,3-bis(2-pyridyl)pyrazine in methanol, with subsequent addition of acetylacetone, the resulting solution is filtered and slowly evaporated with the formation of single crystals of the above compound, which comprises a new monodeprotonated ligand 1-(7-chloro-6-methyl-2,3-bis(pyridin-2-yl)-5H-cyclopenta[b]pyrazin-5-yl)ethanone, produced as a result of condensation reaction of 2,3-bis(2-pyridyl)pyrazine and acetylacetone ligands.