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Hyperbaric device and methods for producing inactivated vaccines and refolded/solubilized recombinant proteins
Hyperbaric device and methods for producing inactivated vaccines and refolded/solubilized recombinant proteins
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机译:用于生产灭活疫苗和重折叠/增溶重组蛋白的高压装置和方法
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摘要
The invention relates to hyperbaric devices for inactivating microorganisms and viruses while retaining their immunogenicity and for making and producing the soluble, disaggregated, refolded or active immunogenic or therapeutic proteins from inclusion bodies produced from prokaryotes or eukaryotes. The invention encompasses hyperbaric methods for inactivating pathogenic organisms and methods for producing vaccine compositions using the inactivated pathogens. The hyperbarically inactivated microorganisms are safer and more immunogenic than chemically inactivated microorganisms. Similarly, the solubilized proteins have superior properties compared to more heavily aggregated proteins, including reduced non-specific immune reactions.
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