PREPARATION METHOD FOR EUTECTIC HYDRATE CRYSTAL FORM II OF AHU-377 AND DIOVAN TRISODIUM SALT.

摘要

Disclosed is a preparation method for a eutectic hydrate crystal form II of AHU-377 and diovan trisodium salt, comprising: firstly, obtaining a clear solution of an AHU-377 and diovan trisodium salt compound, a solvent of the clear solution consisting of an anti-solvent and an n-solvent of a target product crystal form II, and the boiling point of the n-solvent being lower than that of the anti-solvent; secondly, removing the n-solvent and water from a system by evaporation under closed conditions; and finally, selectively adding a seed crystal of the crystal form II, and additionally adding a mixture of water and a carrier solvent to perform stirring crystallization. The method in the present invention can prepare a crystal form II, and has a stable and controllable technological process. The prepared crystal form II product is high in chemical purity, crystal form purity and fluidity, the process can be amplified, and demands for large-scale production are met.