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STRUCTURE-BASED PEPTIDE INHIBITORS OF ALPHA-SYNUCLEIN AGGREGATION.
STRUCTURE-BASED PEPTIDE INHIBITORS OF ALPHA-SYNUCLEIN AGGREGATION.
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机译:α-突触核蛋白凝集的基于结构的肽抑制剂。
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摘要
This invention relates to inhibitory peptides which bind to a-synuclein molecules and inhibit a-synuclein amyloidogenic aggregation, a-synuclein cytotoxicity, and spread of a-synuclein. Methods of making and using the inhibitory peptides (e.g. to treat subjects having conditions or diseases that are mediated by a-synuclein, such as Parkinson's disease, dementia with Lewy bodies, or MSA) are described.
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