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NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF DENGUE VIRUS.
NOVEL VACCINES AGAINST MULTIPLE SUBTYPES OF DENGUE VIRUS.
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机译:针对登革热病毒多种亚型的新型疫苗。
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摘要
An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.
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