C-glucoside derivative containing fused phenyl ring or pharmaceutically acceptable salt thereof, process for preparing same, and pharmaceutical composition comprising same

摘要

The present invention relates to a C-glucoside derivatives of Formula I containing a fused phenyl ring or a pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition comprising the same, a use thereof, and a double inhibition process of SGLT1 and SGLT2 using the same; wherein X and Y are each independently -CH2- or -O-, wherein both X and Y are not -O- at the same time; m is 1; R1 is methyl; and the remaining substituents are as defined herein. Representative compounds of formula (I) include (2R,3S,4R,5R,6S)-2-(hydroxymethyl)-6-(7-(4-methoxybenzyl)-4-methyl-2,3-dihydro-1H-indene-5-yl)tetrahydro-2H-pyran-3,4,5-triol and (2S,3R,4R,5S,6R)-2-(7-(4-ethoxybenzyl)-4-methyl-2,3-dihydrobenzofuran-5-yl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol. A novel compound of the present invention has a double inhibitory activity of SGLT1 and SGLT2, and can be effectively used as a therapeutic agent for diabetes.