MAGNESIUM-IRON LAYERED DOUBLE HYDROXIDES, THEIR MANUFACTURE AND THEIR USE FOR TREATMENT OF HYPERPHOSPHATAEMIA

摘要

There is provided a method of producing a mixed metal compound comprisingat least Mgsup2+/supand at least Fesup3+/suphaving an aluminium content of less than 10000 ppm,having an average crystal size of less than 20nm (200A)comprising the steps of:(a) combining a Mgsup2+/supsalt and a Fesup3+/supsalt with Nasub2/subCOsub3/suband NaOH to produce a slurry, wherein the pH of the slurry is maintained at from 9.5 to 11 , and wherein the Nasub2/subCOsub3/subis provided at an excess of 0 to 4.0 moles than is required to complete the reaction(b) subjecting the slurry to mixing under conditions providing a power per unit volume of 0.03 to 1.6kW/msup3/sup(c) separating the mixed metal compound from the slurry, to obtain a crude product having a dry solid content of at least 10 wt%(d) drying the crude product either by(i) heating the crude product to a temperature of no greater than 150°C and sufficient to provide a water evaporation rate of 0.05 to 1.5 kg water per hour per kg of dry product, or(ii) exposing the crude product to rapid drying at a water evaporation rate of 500 to 50000 kg water per hour per kg of dry product.