HIGH SPEED DEEP TISSUE IMAGING SYSTEM USING MULTIPLEXED SCANNED TEMPORAL FOCUSING

摘要

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property MD 1101111 0 DOI HIM 011101 0 0111111111111111M 111111111111111111111111 Organization International Bureau (10) International Publication Number (43) International Publication Date .....0""" WO 2018/081711 Al 03 May 2018 (03.05.2018) W I P0 I P C T (51) International Patent Classification: (72) Inventor; and GO1N 21/63 (2006.01) HOlS 3/067(2006.01) (71) Applicant: VAZIRI, Alipasha [US/US]; 1161 York Av- GO1N 21/64 (2006.01) enue, #11E, New York, NY 10065 (US). (21) International Application Number: (74) Agent: ZUSCHLAG, Steven T.; Hoffmann & Baron, LLP, PCT/US2017/059044 6900 Jericho Turnpike, Syosset, New York 11791 (US). (22) International Filing Date: (81) Designated States (unless otherwise indicated, for every 30 October 2017 (30.10.2017) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, (25) Filing Language: English CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, (26) Publication Language: English DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (30) Priority Data: HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, 62/414,788 30 October 2016 (30.10.2016) US KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (71) Applicant: UNIVERSITY OF VIENNA [AT/AT]; Uni- OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, versitatsring 1, A-1010 Vienna (AT). SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (54) Title: HIGH SPEED DEEP TISSUE IMAGING SYSTEM USING 139 FCPA DOE MULTIPLEXED SCANNED TEMPORAL FOCUSING 501, _. 520 , '---, 503 '- 509 530 515 1 z - - - 1. '- - - - 1 5141 4- 511 505 - T 1 , 516' _6. ky - 500 +10n..s. 507-,- 513 1 '' 518 ,-, (57) : A tissue imaging system Il laser pulse received from the laser module 1-1 IN optical delay module to a target volume 1-1 to excitation of the target volume by the X ) configured to receive the temporally multiplexed 0 ---. laser pulse into a plurality of sub-beams GC sub-beam are spatially separated with respect to a first image plane formed at a first depth within 1-1 c;;;;) to a second image plane formed at a second ei +2Ons ' L FIG. 5 includes a laser module for outputting a laser pulse, an optical delay module configured to split a into a plurality of time-delayed sub-pulses, a telescope for delivering the sub-pulses from the and a photodetector configured to collect photons generated within the target volume in response first and second sub-pulses. The system may further laser pulse from the optical delay module and including a first sub-beam and a second sub-beam, wherein the first sub-beam and the second depth within the target volume. include a spatial multiplexing module splitting the temporally multiplexed the target volume and with respect O [Continued on next page] WO 2018/081711 Al MIDEDIMOMBEFIDIONIMHOIniliMEMOIMIE (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Published: — with international search report (Art. 21(3))