COMBINATION THERAPIES FOR TREATMENT OF BCMA-RELATED CANCERS AND AUTOIMMUNE DISORDERS

摘要

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date IiiimmoimiolollmonolomolEmolmoolliflovoimIE (10) International Publication Number WO 2018/151836 Al 23 August 2018 (23.08.2018) WIPOIPCT (51) International Patent Classification: (72) Inventors: RIDDELL, Stanley, R.; 1763 268th Place SE, A61K 31/55 (2006.01) A61P 35/02 (2006.01) Sammamish, WA 98075 (US). GREEN, Damian; 2746 NE A61K 39/395 (2006.01) A61P 37/00 (2006.01) 88th Street, Seattle, WA 98115 (US). HILL, Tuler; 1315 A61K 35/17 (2015.01) A61K 45/06 (2006.01) N 88th Street, Seattle, WA 98103 (US). A61P 37/02 (2006.01) Cl 2N 15/62 (2006.01) A61P 35/00 (2006.01) (74) Agent: PEPE, Jeffrey, C. et al.; Seed Intellectual Property, Law Group LLP, 701 Fifth Avenue, Suite 5400, Seattle, WA (21) International Application Number: PCT/US2018/000050 (22) International Filing Date: 16 February 2018 (16.02.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/460,612 17 February 2017 (17.02.2017) US 62/582,270 06 November 2017 (06.11.2017) US (71) Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER [US/US]; 1100 Fairview Avenue North, Seattle, WA 98109 (US). 98104-7064 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, (54) Title: COMBINATION THERAPIES FOR TREATMENT OF BCMA-RELATED CANCERS AND AUTOIMMUNE DISORDERS C113ST 0mg/kg C113ST 3C mg/kg FMC63 30mg/kg •• , ;A.,. 49043001ft 4 , 0PC4 A 1 4 . A Oe ? 49$1 VP 4VQ30:0101 )40: C g C :4' 114. I I GC kr) 00 O 1-1 1-1 N C 0 ( .2 H FIG. 7B (57) : The present disclosure relates to methods for using BCMA-specific binding molecules (such as a BCMA-specific chimeric antigen receptor or antibody) in combination with y-secretase inhibitors, which can be done concurrently or sequentially, to treat or prevent a B-cell related proliferative disease, such as a cancer or autoimmune disease, or the like. A BCMA-specific binding molecule in combination with y-secretase inhibitor can be used in, for example, adoptive immunotherapy. [Continued on next page] WO 2018/151836 Al MIDEDIMOMOIDEIREE3110111MOROMEEN GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))