首页> 外国专利> 'USE OF A PEPTIDE DERIVED FROM HUMAN PROTEIN NTIMP3 IN THE TERAPY OF DIABETICAL NEGOTIATION'

'USE OF A PEPTIDE DERIVED FROM HUMAN PROTEIN NTIMP3 IN THE TERAPY OF DIABETICAL NEGOTIATION'

机译:“人类蛋白NTI MP3衍生肽在糖尿病治疗中的应用”

摘要

The present invention relates to fusion peptides consisting of the peptide fragment corresponding to the N-terminal domain derived from the human TIMP3 protein, both in native and mutated form, bound by the N-terminal end to a highly selective and efficient carrier peptide for transport in renal proximal tubule cells, the medical use thereof, in particular the use thereof in the treatment of diabetic nephropathy, and the compositions comprising them.
机译:本发明涉及融合肽,该融合肽由天然和突变形式的与衍生自人TIMP3蛋白的N端结构域相对应的肽片段组成,所述肽片段以N端结合至高度选择性和有效的载体肽以进行转运在肾近端肾小管细胞中的“抗氧化剂”,其医学用途,特别是其在治疗糖尿病性肾病中的用途,以及包含它们的组合物。

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