Modified release therapeutic systems for the oral administration of menthol in the treatment of intestinal disorders

摘要

Colon-specific monolithic delayed release pharmaceutical compositions comprising: a) a core with a monolithic matrix comprising hydroxypropylmethylcellulose wherein the menthol is dispersed in ground, comminuted or micronized form with a particle size ranging from 100 nm to 1200 μm, b) a gastroresistant coating of core a), wherein the weight ratio of menthol to hydroxypropylmethylcellulose ranges from 1: 5 - 4: 1