Triazolo 4,5-d pyrimidine derivatives as cb2 receptor antagonists

摘要

A compound of formula (I) ** Formula ** wherein R 1 is haloalkyl, halophenyl, alkoxyphenyl, alkyl-1,2,5-oxadiazolyl, haloalkylphenyl, alkylsulfonylphenyl, halopyridinyl or alkyltetrazolyl; R2 is alkylamino, cycloalkylamino, alquiloxetanilamino, (cycloalkyl) (alkyl) amino, haloalkyloxy, alkoxy, cycloalkylalkoxy, cycloalkyloxy, oxetanyloxy, alquiloxetanilalquiloxi, alkynyloxy, alkoxyalkoxy, hydroxyalkyloxy, alkylsulfanyl, haloalkylsulfanyl, alkylsulfonyl, hidroxialquilsulfanilo, hydroxyalkylsulfonyl or alcoxialquilsulfonilo; R3 and R4 are independently selected from hydrogen, halogen, hydroxyl, alkylcarbonylamino and alkyl, provided that both R3 and R4 are not hydrogen at the same time; and n is 1 or 2; or a pharmaceutically acceptable salt or ester thereof; provided that (S) -1- [3- (4-methoxy-benzyl) -5- (2,2,2-trifluoro-ethoxy) -3H- [1,2,3] triazolo [4,5- d] pyrimidin-7-yl] -pyrrolidin-3-ol.