BLONANSERIN-CONTAINING PATCH PREPARATION

摘要

A patch preparation containing a support and an adhesivelayer formed on one surface of the support, wherein theadhesive layer contains 2-(4-ethyl-1-piperazinyl)-4-(4-fluorophenyl)-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine or aphysiologically acceptable acid addition salt thereof, anacrylic polymer, lactic acid, sesame oil and one or more kindsof stabilizers selected from 2-mercaptobenzimidazole, 2,6-di-tert-butyl-4-methylphenol and propyl gallate.A patch preparation containing a support and an adhesivelayer containing lactic acid and magnesium aluminometasilicateand formed on at least one surface of the support, whichpreparation is superior in both skin permeability andadhesiveness in the presence of water.