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RAPID, MASSIVELY PARALLEL SINGLE-CELL DRUG RESPONSE MEASUREMENTS VIA LIVE CELL INTERFEROMETRY
RAPID, MASSIVELY PARALLEL SINGLE-CELL DRUG RESPONSE MEASUREMENTS VIA LIVE CELL INTERFEROMETRY
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机译:通过活细胞干涉快速,大量并行的单细胞药物反应测量
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摘要
A central question in cancer therapy is how individual cells within a population of tumor cells respond to drugs designed to arrest their growth. However, the absolute growth of cells, their change in physical mass, whether cancerous or physiologic, is difficult to measure directly with traditional techniques. Embodiments of the invention provide live cell interferometry (LCI) for rapid, realtime quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides a conceptual advance for assessing cell populations to identify, monitor, and measure single cell responses, such as to therapeutic drugs.
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