- Rapid massively parallel single-cell drug response measurements via live cell interferometry

摘要

The central question in cancer therapy is the response pattern of individual cells in a tumor cell population to drugs designed to stop the growth of tumor cells. However, absolute growth of cells, changes in physical mass, whether cancerous or physiological, are difficult to measure directly by the prior art. Embodiments of the present invention provide live cell interferometry (LCI) for rapid, real-time quantification of cell mass in cells exposed to a changing environment. Overall, LCI provides conceptual advances in evaluating cell populations to identify, monitor, and measure single cell responses such as therapeutic drugs.