AAV MEDIATED AQUAPORIN GENE TRANSER TO TREAT SJOGREN'S SYNDROME

摘要

The invention relates to a gene transfer-based method to protect a subject from Sjogren's syndrome. The method comprises administering to the subject an AAV virion comprising an AAV vector that encodes aquaporin- 1 (AQP-1) protein. Also provided are AQP-1 proteins and nucleic acid molecules that encode such proteins. Also provided are AAV vectors and AAV virions that encode an AQP- 1 protein.