PRODUCTION METHOD FOR CAPSULAR POLYSACCHARIDE HAVING PNEUMOCOCCAL SEROTYPE

摘要

The present invention provides an improved method of producing a capsularpolysaccharidehaving a pneumococcal serotype. The method according to the present inventionincludes astep of additionally culturing bacterial cells producing a pneumococcalserotype without pHadjustment, thereby removing a protein precipitation process by acidificationwith a pH adjuster.