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RECOMBINANT ACETOGENIC BACTERIUM WITH MUTATED LACTATE BIOSYNTHESIS PATHWAY ENZYME AND METHODS OF USE THEREOF
RECOMBINANT ACETOGENIC BACTERIUM WITH MUTATED LACTATE BIOSYNTHESIS PATHWAY ENZYME AND METHODS OF USE THEREOF
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机译:重组乳酸菌发酵乳酸盐生物合成途径酶及其使用方法
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摘要
The invention provides a carboxydotrophic acetogenic bacterium comprising a disrupting mutation in a lactate biosynthesis pathway enzyme and a method of producing a product by culturing the bacterium in the presence of a substrate comprising carbon monoxide. Preferably, the lactate biosynthesis pathway enzyme is lactate dehydrogenase (LDH) or another enzyme that converts pyruvate to lactate, wherein the disrupting mutation reduces or eliminates the expression or activity of the enzyme such that the bacterium produces a reduced amount of lactate or no lactate.
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