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A PERIPHERALLY-RESTRICTED DUAL-ACTING KAPPA AND DELTA OPIOID AGONIST FOR ANALGESIA IN PAIN STATES INVOLVING THE INFLAMMATORY RESPONSE
A PERIPHERALLY-RESTRICTED DUAL-ACTING KAPPA AND DELTA OPIOID AGONIST FOR ANALGESIA IN PAIN STATES INVOLVING THE INFLAMMATORY RESPONSE
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机译:疼痛状态涉及炎症反应的痛觉抑制的永久性双作用Kappa和δ阿片类药物
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摘要
The present disclosure teaches the use of a dual-acting opioid agonist for the treatment of pain (e.g., inflammatory pain). The opioid agonist activates both the kappa and delta opioid receptors to provide synergistic reduction in pain. The opioid agonist is peripherally restricted and does not cross the blood-brain barrier.
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